Crystal structures of influenza nucleoprotein complexed with
WEB19. Apr. 2021 · Abstract. The nucleoprotein (NP) of influenza virus is the core component of the ribonucleoprotein (RNP) and performs multiple structural and functional roles. Structures of the influenza A, B and D NP molecules have been solved previously, but structural information on how NP interacts with RNA remains elusive.
The structure of the influenza A virus genome | Nature …
WEB22. Juli 2019 · In influenza virions, as well as in infected cells, RNA genome segments are assembled into vRNP complexes where the termini of viral RNA associate with viral RNA-dependent RNA polymerase while...
Contribution of the Nuclear Localization Sequences of Influenza A ...
WEB28. Juli 2023 · Our findings indicate that both NLS1 and NLS2 have to be present for successful infection and demonstrate the crucial role of these two NLSs in the infection cycle of the influenza A virus. Keywords: NLS; influenza A virus; nuclear import; nuclear localization sequence; nucleoprotein.
Nucleotide resolution mapping of influenza A virus ... - Nature
WEB31. Jan. 2018 · Influenza A virus nucleoprotein (NP) association with viral RNA (vRNA) is essential for packaging, but the pattern of NP binding to vRNA is unclear. Here we applied photoactivatable...
Cryo-EM structure of influenza helical nucleocapsid reveals
WEBScience Advances. 15 Dec 2023. Vol 9, Issue 50. DOI: 10.1126/sciadv.adj9974. Abstract. Influenza virus genome encapsidation is essential for the formation of a helical viral ribonucleoprotein (vRNP) complex composed of nucleoproteins (NP), the trimeric polymerase, and the viral genome.
A structural understanding of influenza virus genome replication
WEB3. Nov. 2022 · viral genome. RNA replication. nucleoprotein. ANP32. Influenza virus RNA polymerase. Influenza viruses belong to the family Orthomyxoviridae and are divided into four types: A, B, C, and D viruses [ 1. ].
How viruses access the nucleus - ScienceDirect
WEB1. Sept. 2011 · The influenza A virus is an enveloped virus, containing a segmented genome consisting of eight single-stranded negative-sense RNAs. While most RNA viruses replicate in the cytoplasm, influenza replication takes place in the nucleus, likely due to the requirement for cellular splicing machinery present there (reviewed in [62] ).
RNA sequence features are at the core of Influenza A virus …
WEB4. Okt. 2019 · Introduction. Influenza A virus (IAV), a member of the Orthomyxoviridae family, has a negative-sense, segmented, single-stranded RNA genome. It is composed of eight viral RNA (vRNA) segments that vary in length between 890 and 2341 nucleotides and each vRNA encodes for at least one viral protein.
The structure of the influenza A virus genome
WEBInfluenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA segments contained in separate viral ribonucleo-protein (vRNP)...
Nucleotide resolution mapping of influenza A virus ... - PubMed
WEB31. Jan. 2018 · Influenza A virus nucleoprotein (NP) association with viral RNA (vRNA) is essential for packaging, but the pattern of NP binding to vRNA is unclear. Here we applied photoactivatable ribonucleoside enhanced cross-linking and immunoprecipitation (PAR-CLIP) to assess the native-state of NP-vRNA interactions in infected human cells.
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